The Southern Conference side will play Central at Wanganui with a one-day game on Sunday followed by a four-day match to start on Monday.
Germon and Priest will be out for the whole series while the Southern team also loses Otago pace bowler Robert Kennedy for the first game because of injury.
Southern coach Warren Lees has named a 13-player squad to allow flexibility in selection and to cover for possible injury.
squad: Darrin Murray (captain), Craig Cumming, Robert Lawson, Chris Gaffaney, Llorne Howell, Mark Richardson, Martin Croy, Paul Wiseman, Nathan Morland, Warren Wisneski, Shane Bond, David Sewell, Aaron Gale.
Meanwhile, all-rounder Wayne Stead and wicketkeeper Mark Lane have come into the Canterbury team for the Cricket Max league game against Auckland at Lancaster Park tonight.
Convener of selectors Brian McKechnie had to make the changes because of a knee injury to Glenn Muir and the unavailability of Lee Germon.
Stead, who joins brother Gary in the team, has been in good club form this season and had a fine all-round performance for a Canterbury XI against Auckland two weeks ago. Against Auckland, Wayne Stead scored 35 not out and then took four wickets for 35 runs with his medium-pacers.
Canterbury will be looking for its second straight success under lights after a come-from-behind 47-run win over Max champion Central Districts in Wanganui last Friday night. Auckland also started with a win, beating Wellington by nine wickets.
The Canterbury team for the 7pm game is: Darrin Murray (captain), Blair Hartland, Brad Doody, Mark Lane, Gary Stead, Craig Cumming, Llorne Howell, Shane Bond, Warren Wisneski, Mark Priest, Michael Owens, Wayne Stead.